Searches were conducted using combinations of keywords and Medical Subject Headings (MeSH) terms related to incretin-based therapies and obesity, including GLP-1 receptor agonists, dual agonists, triple agonists, liraglutide, semaglutide, tirzepatide, mazdutide, retatrutide, adolescent obesity, and pediatric obesity
Search and selection strategy A literature search was performed that identified randomised clinical trials of semaglutide published up to 12 November 2023
Contact your GP or healthcare professional if you experience: Persistent vomiting lasting more than 2448 hours, particularly if you cannot keep down fluids Signs of dehydration including dark urine, dizziness, dry mouth, reduced urination, or feeling faint when standing Abdominal pain , especially if severe, constant or located in the upper abdomen radiating to the back Visual changes in vomit, such as blood (appearing red or resembling coffee grounds) Inability to take other essential medications due to vomiting Significant weight loss beyond expected therapeutic effects Symptoms of gallbladder disease including pain in the upper right abdomen, fever, or yellowing of the skin/eyes Symptoms of bowel obstruction such as abdominal distension, inability to pass stool or gas If your GP is unavailable, contact NHS 111 for advice
Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study
Adding a medication known to cause nausea and vomiting could worsen this significantly, potentially leading to hyperemesis gravidarum (severe pregnancy-related vomiting requiring medical intervention)